Overview

Reata is also currently developing bardoxolone methyl in 4 other rare forms of CKD for which there are unmet needs:

  • Autosomal dominant polycystic kidney disease (ADPKD)
  • IgA nephropathy (IgAN)
  • Type 1 diabetic CKD (T1D CKD)
  • Focal segmental glomerulosclerosis (FSGS)

Combined, these rare diseases represent a patient population of more than 500,000. The clinical activity observed in patients with ADPKD, IgAN, and T1D CKD suggests that bardoxolone methyl targets the final common pathway of kidney function loss relevant to many forms of CKD.

Chronic inflammation is a common mechanism underlying the development and progression of several CKD states. Inflammatory mediators can cause sustained injury that spreads from the glomerulus to the tubules, leading to inflammation, fibrosis, progressive loss of kidney function and ESRD.1,6 Reata is studying the effects of bardoxolone methyl to intervene in the inflammatory process and help preserve kidney function.

References
  1. Noone D, Licht C. An update on the pathomechanisms and future therapies of Alport syndrome. Pediatr Nephrol. 2013;28(7):1025-1036.
  2. Li X, Magenheimer BS, Xia S, et al. A tumor necrosis factor-alpha-mediated pathway promoting autosomal dominant polycystic kidney disease. Nat Med. 2008;14(8):863-868.
  3. Penfold RS, Prendecki M, McAdoo S, Tam FW. Primary IgA nephropathy: Current challenges and future prospects. Int J Nephrol Renovasc Dis. 2018;11:137-148.
  4. Qian Y, Feldman E, Pennathur S, Kretzler M, Brosius FC. From fibrosis to sclerosis: Mechanisms of glomerulosclerosis in diabetic nephropathy. Diabetes. 2008;57(6):1439-1445.
  5. Kim JS, Han BG, Choi SO, Cha SK. Secondary focal segmental glomerulosclerosis: From podocyte injury to glomerulosclerosis. Biomed Res Int. 2016;2016:1630365.
  6. Savige J. Alport syndrome: Its effects on the glomerular filtration barrier and implications for future treatment. J Physiol. 2014;592(18):4013-4023.
View References